Palabras clave
tumor mülleriano mixto
sarcoma
carcinosarcoma
condrosarcoma
Uterine cervix
mixed Müllerian tumor
chondrosarcoma
Resumen
Introducción: Reporte de caso de sarcoma mülleriano mixto maligno de cuello uterino, neoplasia extremadamente rara con pocos casos globales documentados. Resumen del caso: Femenina, 60 años, presentó sangrado vaginal leve, intensificándose último mes, sometida a histerectomía total abdominal con salpingooforectomía bilateral. El análisis histopatológico reveló tumor mülleriano mixto maligno con componente heterólogo, invasión a istmo, infiltración linfática y vascular, bordes quirúrgicos libres, ovarios con cuerpos albos, trompas de Falopio y endometrio secretor sin evidencia neoplásica. Discusión: Los sarcomas cervicales son excepcionales, el carcinosarcoma el subtipo más común, seguido por adenosarcoma y leiomiosarcoma. El condrosarcoma cervical es una variante histológica extremadamente rara, el cual destaca por su combinación histológica inusual y su comportamiento agresivo. Conclusiones y recomendaciones: Este caso ilustra desafíos diagnósticos y terapéuticos, debido a su similitud con entidades benignas. Los hallazgos histopatológicos y evolución clínica destacan la necesidad de investigaciones que identifiquen perfiles moleculares específicos para personalizar opciones terapéuticas.
Malignant mixed Müllerian sarcoma of the cervix: Case report
Summary
Introduction: Case report of a malignant mixed Müllerian sarcoma of the cervix, an extremely rare neoplasm with few documented cases worldwide. Case summary: A 60-year-old female presented with mild vaginal bleeding, which intensified in the last month. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy. Histopathological analysis revealed a malignant mixed Müllerian tumor with a heterologous component, isthmus invasion, lymphatic and vascular infiltration, free surgical margins, ovaries with corpora albus, fallopian tubes, and secretory endometrium with no evidence of neoplasia. Discussion: Cervical sarcomas are rare, with carcinosarcoma being the most common subtype, followed by adenosarcoma and leiomyosarcoma. Cervical chondrosarcoma stands out for its unusual histological combination and aggressive behavior. Conclusion: This case of cervical sarcomas illustrates the diagnostic and therapeutic challenges due to their similarity to benign entities; The histopathological findings and clinical course of the case highlight the need for research to identify specific molecular profiles that allow for personalized therapeutic options.
Citas
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