Abstract
On February 27, the first case of COVID-19 was confirmed in Mexico, a disease caused by the SARS Cov-2 virus. Until August 7, data from the John Hopkins University show 201 million infected, while in Mexico 2.94 million infected in the world, causing 4.27 million deaths. Objective: To describe the clinical behavior and characteristics associated with seve- rity/mortality in COVID-19. Methods: Data from 280 patients confirmed to COVID-19 by RT PCR were obtained, with moderate and severe clinical expressions that warranted hospital management at the High Specialty Medical Unit in Puebla from March 1 to June 30, 2020. Results: The mean age was 54.31 years and 63.57% (n = 178) were men. The comorbidities found were overweight: 49.28% (n = 138), obesity: 35% (n = 98), systemic arterial hypertension: 25.35% (n = 71), diabetes mellitus: 24.64% (n = 69), kidney transplantation: 5% (n = 12). Respiratory symptoms were reported in 86.07% (n = 241). Of the total number of patients, only 15.71% (44) re- quired ventilatory mechanical assistance. The risk factors associated with death were Systemic Arterial Hypertension (SAH) OR = 5.31 (95% CI 2.14- 12.75), Male sex OR = 4.77 (95% CI 1.65-13.84), Mechanical-Ventilatory Assistance (AMV) OR = 3.2 (95% CI 1.3-7.86), transplantation OR= 102 (95% CI 14.91-699) and there was a protective factor called respiratory symptoms OR = 0.12 (95% CI 0.05-0.3). Conclusion: COVID 19 is more prevalent in men. The mortality rate was 17.5% (49/280). The risk factors for mortality were SAH, male sex, AMV, Transplantation and finally, respiratory symp- tom was a protective factor.
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